Nephron formation in the MM requires reciprocal interaction with the UB tips. The proper elaboration of the UB tree and the secretion of tip-derived signals are essential for adequate nephrogenesis.

ClC-K2 is expressed more broadly in the distal nephron; expression levels are highest along the thick ascending limb of the loop of Henle and distal convoluted tubule. Expression of ClC-K1 is ...