Using a xenogeneic model of GvHD in NOD/SCID/γc− (NSG) mice, we showed that weekly administration of IVIG significantly reduced the incidence and associated mortality of GvHD to a degree ...
However, human T cells did not develop in humanized NOD-SCID mice, and B cells did not mature into immunoglobulin-producing cells (probably because of lack of T cell help). Nevertheless ...
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