Using a xenogeneic model of GvHD in NOD/SCID/γc− (NSG) mice, we showed that weekly administration of IVIG significantly reduced the incidence and associated mortality of GvHD to a degree ...

They next had to check that these edited cells could restore immune function in the body. They transplanted these edited human cells into SCID-model mice and found that B and T cells spiked to levels ...

However, human T cells did not develop in humanized NOD-SCID mice, and B cells did not mature into immunoglobulin-producing cells (probably because of lack of T cell help). Nevertheless ...