However, SOS has multiple protein and lipid interactions ... For quantitative and qualitative assays of the RAS-ERK signal module, intracellular staining of BCR-induced ERK phosphorylation was ...

The clustering is a great advantage for Ras. The proteins are able to pass on a signal more clearly in the group, i.e. with fewer errors. The SOS protein, for example, always transmits one signal ...

"Our study showed that, in fact, an important aspect of the SOS signal that activates Ras is encoded in the noise," says Groves. "The protein's dynamic fluctuations between different states of ...

Patients with cancers driven by the protein KRAS ... Title: Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange Authors: Michael Burns1, Qi Sun1 ...