Lagouge et al., "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α," Cell, 127:1109-22, 2006. (Cited in 139 papers) The finding: In 2006 ...

SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches ...

A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas. Individuals who use large amounts of ...

Moreover, inactivation of the SIRT1 gene in mice led to the destruction of the insulin-producing region of the pancreas, resulting in high levels of blood sugar. "The identification of a gene ...

A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas. Individuals who use large amounts of ...