This gene expression program is dependent on the disruptor ... We conducted a genome-scale RNAi screen and found that the histone deacetylase SIRT1 is required for the establishment of a ...

Although no statistically significant difference was observed regarding SIRT1 gene expression, a statistically significant association with FMD in men was observed. Mechanistically, SIRT1 ...

[20] Here we show that inhibiting SirT1 gene expression in the liver and WAT is sufficient to recapitulate the cytokine elevations seen in rodent and human overnutrition, as well as to trigger ...

Gene expression analysis further demonstrated that loss of endogenous Sirt1 inhibited autophagy, which regulates normal gland development. Dr. Pestell's laboratory was the first to show that the ...

SIRT1 appears to protect against cardiac hypertrophy in cardiac and smooth-muscle cells and also protects smooth muscle by inhibiting the expression ... activates the gene encoding the sterol ...

Percutaneous transhepatic biliary drainage in hepatopancreaticobiliary cancer: Contemporary efficacy. This is an ASCO Meeting Abstract from the 2016 ASCO Annual Meeting I. This abstract does not ...

Conclusions—Reduction of adipose tissue SirT1 expression, which leads to histone hyperacetylation and ectopic inflammatory gene expression, is identified as a key regulatory component of ...