The engineered ONYX-015 virus is unable to make E1B-55K, an early adenoviral protein critical for degrading p53 and thus overcoming p53-mediated cell cycle arrest and apoptosis (Biederer et al., ...

In the case of reovirus, TRiC folds a major component ... When TRiC is disrupted, the outer coat cannot form and the cycle of viral replication is broken. This study sheds light on the poorly ...

and allows the virus to replicate in cancer cells (elevated activity of RPK in "normal" cells inhibits reovirus replication). After several rounds of viral replication inside cancer cells ...

Reovirus Serotype 3–Dearing Strain (R ... IP tumors are again biopsied before cycle 3, allowing for the assessment of replication of R after IV and IP administration. Samples of peritoneal fluid are ...

The first abstract, entitled "Reovirus replication in ovarian and peritoneal tumors after intravenous administration," covers correlative results from a Phase 1/2 study with reovirus, sponsored by ...