These are the first data to demonstrate a role for mTOR in the regulation of SKP-2. In concordance with these findings, mTORC2 activity promotes cell proliferation of RCC cells at the G1–S ...

The results have recently been published in eLife. The protein complex mTORC2 plays a crucial role in the regulation of cellular metabolism. It stimulates, for example, the production of lipids ...

two major functions have been attributed to mTORC2: regulation and organization of the actin cytoskeleton and Akt regulation through phosphorylation of its carboxyl terminal. Phosphorylation of ...

"Given that flies and mice last shared a common ancestor 500 million years ago, it is quite remarkable and telling that the function of mTORC2 in the regulation of memory is indeed maintained ...

New results from researchers at MedUni Vienna's Center for Pathobiochemistry and Genetics show that a protein called mTORC2, which is the target of newly developed cancer drugs, is not even active ...

The mTORC2 protein plays an important role in tumorigenesis and is currently the target of a series of new drugs that can successfully inhibit the growth of cancer cells in a test tube.