Here we report the identification of the forkhead/winged-helix transcription factor FOXM1 as a novel downstream target of the Ras–MKK3–p38-signaling pathway in a phenotype-assisted ...

1 One of the most important pathways related to oxidative stress and cancer is the Ras pathway ... relationship between Prx II and Raf/MEK/EKR/FoxM1 signal cascade.

For many years, the Ras signaling pathway has triggered both hope and frustration in the field of cancer research. In normal health, Ras signaling is central to the regulation of intracellular ...

All Ras proteins are GTPases which act as molecular switches in the cell, regulating signaling pathways and other interactions. Ras proteins are normally tightly regulated by factors that switch ...

Erasca, Inc. presents promising preclinical data on ERAS-0015 and ERAS-4001 targeting RAS/MAPK pathway cancers at AACR meeting. Erasca, Inc. presented new preclinical data at the American ...

"In our study published earlier this month in EMBO Reports we conducted genome wide screens in mesothelioma cells and uncovered that the RAS pathway causes resistance to TEAD inhibition.

potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition. VS-6766 is currently in late-stage development. In contrast to currently available MEK ...

It is encouraging that the development of mechanism-based therapies that inhibit the over-activated RAS pathway and other RAS-connected pathways opens new avenues of therapeutic intervention for the ...