Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation ... from Sigma. The anti–phospho-Cdk9 (Thr186), and anti–phospho-Cdk7 (Thr170), used in ChIP and ...

When an antibody that targets RNA polymerase II (Pol II) is used ... we caution against using phospho-CTD antibodies as the sole method for establishing the presence of a paused Pol II.

mRNA transcription by RNA polymerase II (Pol II) is rapidly regulated in response to many different types of cellular stress, including heat shock. In response to heat shock in human cells, several ...

The authors first sought to understand how these drugs affected RNA Pol II dynamics and assessed genomic distribution of both paused and elongating Pol II using the Henikoff lab’s bread and butter ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...