Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Scientists have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate -- a molecule generated in the body from the breakdown of sugars ...

This gene is present in the liver and red blood cells, containing instructions to make the pyruvate kinase enzyme. If there is a change in the gene's structure, it does not code properly for the ...

AHAS is a thiamine diphosphate (ThDP)-dependent enzyme that belongs to the pyruvate oxidase (PO)-like subfamily. The members of this family all share a similar three-dimensional crystal structure.

Pyruvate kinase deficiency is caused by mutations in PKLR and leads to congenital hemolytic anemia. Mitapivat is an oral, small-molecule allosteric activator of pyruvate kinase in red cells ...