Figure 1: Proteomic screen identifies pyruvate kinase as a novel phosphotyrosine-binding protein. Figure 2: Phosphopeptide binding is specific to the M2 isoform of pyruvate kinase and involves ...

The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of PKM2 with phosphotyrosine-containing proteins inhibits enzyme activity and ...

Proliferating cells, in particular tumor cells, are characterized by a high amount of the dimeric form of the pyruvate kinase isoenzyme type M2 (Tumor M2-PK). Tumor M2-PK can be determined in EDTA ...

"This finding was particularly interesting because previous reports had shown that this M2 form was the pyruvate kinase form used by all cancer cells." In order to understand the implications of ...

Discovered eighty years ago by Nobel Prize-winning scientist Otto Warburg, this altered metabolism in cancer cells is most critically mediated by a protein called PK-M2 (pyruvate kinase M2).

Second primary cancers in young adult colorectal cancer survivors. This is an ASCO Meeting Abstract from the 2015 Gastrointestinal Cancers Symposium. This abstract does not include a full text ...

Diversity, equity, and inclusion (DEI) champions: Lessons learned and implications for future programming to support cancer clinical trials. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...

view more Pyruvate kinase (PK), an omnipresent and functionally important enzyme, catalyzes the conversion of ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate. The reaction, physiologically ...

HEREDITARY spherocytosis with its associated congenital hemolytic anemia is generally easily recognized and satisfactorily treated with splenectomy. A rarer group of congenital hemolytic anemias, h ...

Pyruvate kinase deficiency is a genetic disorder affecting red blood cells that carry oxygen to all cells in the body. People with pyruvate kinase deficiency have chronic hemolytic anemia ...

Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...