Both single- and double-stranded DNA features interact with RAD52 and hold the structure in place, allowing the team to obtain a detailed 3D structure of the whole protein-DNA complex.

The central dogma of molecular biology is that the one-dimensional (1D) sequence of DNA bases (A ... takes as input the 1D sequence of a protein of unknown structure and a multiple sequence ...

Varshavsky studied chromatin structure and wanted to develop new methods to detect the DNA-protein interplay in intact cells. Motivated to better understand chromatin structural organization, ...

“How do proteins respond to DNA damage; how do they find ... coded confidence scale for its predictions. Areas of a protein structure colored blue indicate high confidence, while red areas ...

“Structure doesn’t tell you everything ... such as those gnarly but important protein complexes. Massive amounts of DNA generated by the Human Genome Project have made a wide range of ...

Recognition of a DNA mismatch by a dimeric MutS protein initiates a cascade of ... Here we present the crystal structure at 2.2 Å of MutS from Escherichia coli bound to a G·T mismatch.

Until now such synonymous changes in DNA were deemed “silent” mutations that did not affect the structure or function of the resulting protein. Chemists at Pennsylvania State University have ...

DeepPBS allows scientists and researchers to input the data structure of a protein–DNA complex into an online computational tool. Structures of protein–DNA complexes contain proteins that are ...

As a postdoc, Komor found a way to achieve gene-editing with higher efficiencies and a lower incidence of indels by avoiding ...

Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear ...

The prize goes to David Baker “for computational protein design,” and to Demis Hassabis and John Jumper “for protein structure prediction ... that fix damaged DNA. Their list of roles ...