Codeine phosphate 10mg, promethazine HCl 6.25mg; per 5mL; syrup; contains alcohol 7%. Risk of life-threatening respiratory depression and death related to ultra-rapid metabolizers of codeine (esp.

The pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories at three dosage strengths and oral syrup were studied. The study had an open-label, randomized ...