Figure 1: The pre-replication complex and Meier-Gorlin syndrome. In family 6, three affected children were compound heterozygotes for mutations in ORC6. Similar to P5, these children inherited one ...

In human cells, ORC assembles at literally thousands of origin sites across the entire genome, to form an initial configuration called the pre-replication complex, or pre-RC. Once assembled ...

As the zipper opens (or the strand divides), the DNA’s nucleobases are exposed, so that a group of proteins – known as the pre-replication complex – can bind to the single strands and copy ...

When ORC and several other helper proteins attach at these positions, each of the assembled groups of proteins is said to form a pre-replication complex (pre-RC). When pre-RCs have attached at all ...

First, a group of proteins cluster at each origin site to form a pre-replication complex or pre-RC. The phosphorylation of some pre-RC components by DDK in turn recruits other proteins to these ...

A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.

ORC is a six-subunit complex, with each subunit interacting with each other and other proteins to form a pre-replication complex which unwinds double-stranded DNA to start replication. The ...

The researchers suggest that certain cell types, such as chondrocytes, which are prevalent in ears and kneecaps, are more sensitive to an impaired pre-replication complex. They suggest that further ...

When ORC and several other helper proteins attach at these positions, each of the assembled groups of proteins is said to form a pre-replication complex (pre-RC). When pre-RCs have attached at all ...