The exact molecular functions of Polo-like kinase 1 (PLK1) in mitotic prophase are not fully understood. This study shows that PLK1 inhibition delays activation of CDK1-cyclin B and halts cells for ...

The scientists found that an enzyme, called PLK1 (a kinase), is responsible for triggering the formation of the complex. PLK1 is active during normal mitosis, but for unknown reasons only induces ...

and polo-like kinase 1 (PLK1), driving pro-apoptotic cell death. The FDA's breakthrough device designation is given to devices that have the potential to provide effective treatment or diagnosis ...

CDK activation is complex, but is triggered in part by kinases of the Polo family, in particular Polo-like kinase-1 (PLK1) in vertebrates 1. However, these global controllers are not sufficient to ...

It is focused on developing onvansertib, a first-in-class, third-generation Polo-like Kinase 1 (PLK1) inhibitor, in combination with standard-of-care chemotherapy and targeted therapeutics.

The high selectivity and temporal control of these chemical-genetic systems were crucial in revealing new roles of each kinase throughout the cell cycle. For instance, acute inhibition of Plk1 at ...