The exact molecular functions of Polo-like kinase 1 (PLK1) in mitotic prophase are not fully understood. This study shows that PLK1 inhibition delays activation of CDK1-cyclin B and halts cells for ...
Acrivon's pipeline also includes ACR-2316, another clinical-stage asset that is tailored to activate cyclin-dependent kinase 1 (CDK1), CDK2, and polo-like kinase 1 (PLK1), driving pro-apoptotic ...
CDK1 phosphorylation of INCENP on Thr388 creates a binding site for PLK1 (Ref. 108). This interaction is required for the recruitment of PLK1 to kinetochores in mitosis. It also regulates the ...
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