The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...
The E7 viral oncoprotein has been shown to bind to retinoblastoma protein (Rb), releasing E2F ... a specific amino acid difference in their pRb binding site (aspartic acid 21 in HPV-16 E7 vs ...
Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...
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