E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK) complexes. The released E2F promotes the transcription of target genes involved ...
Both the retinoblastoma gene product (pRB) and cyclin A, two of the adenovirus E1A targeted ... and showed that it shares significant homology with p34cdk2, a protein kinase that regulates cell-cycle ...
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