News

Here, we report that pyruvate kinase M2 (PKM2) stabilized mutant EGFR protein by direct interaction and sustained cell survival signaling in lung cancer cells. PKM2 silencing resulted in markedly ...
This study fills the gap by demonstrating that PAK5 promotes PKM2 protein stability through phosphorylation at the Ser519 site, indicating a potential mechanism for PAK5's action in endometriosis.
This study fills the gap by demonstrating that PAK5 promotes PKM2 protein stability through phosphorylation at the Ser519 site, indicating a potential mechanism for PAK5's action in endometriosis.
It all starts with EGFR When the epidermal growth factor receptor (EGFR) on the cell's membrane is activated by a growth factor, the PKM2 protein moves into the cell nucleus, where it binds to the ...
This study fills the gap by demonstrating that PAK5 promotes PKM2 protein stability through phosphorylation at the Ser519 site, indicating a potential mechanism for PAK5's action in endometriosis.
PKM2 is a fascinating protein that has a role in how cells use glucose for energy, but it also moonlights in the immune system, where we have found it can be especially troublesome.
"Until now we've had no way to assess the presence or activity levels of the PKM2 protein involved in that switch," said Corinne Beinat, Ph.D., instructor of radiology in the Radiology/Molecular ...
Crippling a protein that allows cancer cells to grow ... 23 in the Journal of Experimental Medicine. An enzyme called PKM2 (M2 isoform of pyruvate kinase) is ramped up in cancer cells, allowing ...
Researchers at the University of Texas MD Anderson Cancer Center have identified that PKM2 protein has important non-metabolic functions in cancer formation. "Our research shows that although PKM2 ...
It all starts with EGFR When the epidermal growth factor receptor (EGFR) on the cell's membrane is activated by a growth factor, the PKM2 protein moves into the cell nucleus, where it binds to the ...