Background: Tumor cells have been shown to express exclusively the embryonic M2 isoform of pyruvate kinase (PKM2), which is a key enzyme that regulates aerobic glycolysis in tumor cells. Use of RNA ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

In a study newly published in Nature Communications, A research team led by Dr. Ke Zen and Chen-Yu Zhang from Nanjing University reports that pyruvate kinase type M2 promotes tumor cell exosome ...

In a recent study published in the Journal of Biomedical Science, researchers investigate whether M2 macrophage-derived exosomes (M2-Exos) could prevent inflammation-associated damage during ...