In recent years, the field of cancer metabolism has found that cancer cells can manipulate the PKM2 enzyme to grow and thrive. Now a new study finds that cancers also use PKM2 to withstand ...

In the study, Xu and her colleagues found that CARM1 protein modifies a cell metabolism protein, PKM2, and changes its function. This drives the Warburg effect, activating a hallmark of cancer.

Because patients with IPF have lung fibrosis, Sun wondered if complex carbohydrate metabolism was also altered in this condition. Using MALDI-MSI, they observed that glycogen- and N-linked glycan-rich ...

This study demonstrates for the first time that PKM2 plays an essential role in not only switching tumor cell metabolism from oxidative phosphorylation to aerobic glycolysis, but also promoting ...

PKM2 is a fascinating protein that has a role in how cells use glucose for energy, but it also moonlights in the immune system, where we have found it can be especially troublesome.

Published in Cell Metabolism, the research (“Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers”) centers on the function of glycogen accumulation in ...

Glucose enters muscle cells through transport proteins and undergoes phosphorylation by hexokinase, after which it is targeted for glycolysis or glycogen synthesis by glycogen synthase.

Methods: Glycogen content and activity of muscle enzymes with regulatory functions in glycogen synthesis were examined. Results: Testosterone treatment increased glycogen content of extensor digitorum ...