Adding to this complexity is the fact that PKC is activated in response to many signals — it functions in many pathways that are important in tumorigenesis. For example, vascular endothelial ...

These intracellular signaling pathways, also called signal transduction ... Protein kinases such as PKA and PKC catalyze the transfer of phosphate groups from ATP molecules to protein molecules.

advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway. Figure 1 provides an overview of how these pathways may contribute to the pathophysiology. The diabetic ...