Fig 1. PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops. Adapted from Hoeffer and Klann. 35 Mammalian target of rapamycin (mTOR) is a serine-threonine ...

Mutations of the PIK3CA gene may predict response to phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) inhibitors. Concomitant mutations in the mitogen-activated protein ...

They treated 134 of the patients who had PIK3CA mutations, PTEN aberrations or both in early-phase clinical trials that included drugs that block the PI3K/AKT/mTOR pathway. The patients had failed ...

5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and mammalian target of rapamycin (mTOR) inhibitors. Regarding pneumonitis, clinicians should monitor patients at each visit for cough ...