Conditions in the PIK3CA-related overgrowth spectrum (PROS), such as CLOVES syndrome, fibroadipose hyperplasia, and megalencephaly-capillary malformation (MCAP), are very rare diseases.

The PIK3CA gene, which encodes the p110α subunit of phosphoinositide 3-kinase (PI3K), is among the most frequently mutated oncogenes in cancer. These mutations drive tumor progression, metabolic ...

CHICAGO -- Adding the PI3K-pathway inhibitor inavolisib (Itovebi) to palbociclib (Ibrance) and fulvestrant significantly improved survival in advanced breast cancer patients with PIK3CA-mutated ...

Characterization of the microRNAome in a patient with acute myeloid leukemia. Background: The PIK3CA gene is mutated in ∼25% of breast cancer cases and has been proposed as a potential biomarker for ...

“The importance of the PI3K pathway has long been recognized across many cancers, and inavolisib could transform the way breast cancer is treated in patients whose tumors harbor PIK3CA mutations ...

(RTTNews) - Swiss drug maker Roche Group (RHHBY) announced Tuesday the launch of the cobas PIK3CA Mutation Test for patients with advanced or metastatic breast cancer. The cobas PIK3CA Mutation ...

PIK3CA-Related Overgrowth Spectrum is a spectrum of rare conditions and is characterized by atypical overgrowths and anomalies in blood vessels, the lymphatic system and other tissues. Novartis ...

The inavolisib combination has the potential to address resistance to treatment and poor prognosis associated with PIK3CA mutations 2-5 These new data are being presented today in an oral ...