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ING5 inhibits aerobic glycolysis of lung cancer cells: StudyThe study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...
Hosted on MSN2mon
ING5 regulates metabolic reprogramming in lung cancer cellsThe study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...
mitogen-activated protein kinase (MAPK)-activated protein kinase 1; PDK1, 3-phosphoinositide-dependent protein kinase 1; PKB/AKT, protein kinase B; S6K, ribosomal protein S6 kinase.) However ...
glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex 1/2; PDK1, phosphoinositide-dependent kinase 1; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol (4,5 ...
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