The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

PDK1: a determining factor in different metabolic states In the study, PDK1 was identified as a determining factor in different metabolic states. “PDK1 plays a determining role in the energy ...

In order to complete their life cycle within the cell and to produce the next generation of viruses, the viruses depend on the activity of a specific cellular enzyme called PDK1 kinase.

HCT116 and DLD1 (wild type, PDK1−/− and AKT1/2−/−) colon cancer lines were from Dr Bert Vogelstein (Johns Hopkins University, Baltimore, MD, USA). ATG5+/+ and ATG5−/− MEFs were from Dr ...

They then investigated one of the molecules, an enzyme called PDK1, in incubated senescent skin fibroblasts and three-dimensional skin equivalent tissue models. They found that blocking PDK1 led to ...

For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is active in metastasizing cancer cells. But no one knew why. In a new paper published ...

The discovery is published in Nature Metabolism under the title "Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity." The study, which was conducted ...