Notably, platelet-derived growth factor receptor α (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors.

Blocking the PDGFRA signalling pathway leads to tumour cell death In a comprehensive analysis of paediatric HGG cases, PDGFRA mutations and/or amplifications were identified in 15% of cases ...

Blocking the PDGFRA signaling pathway leads to tumor cell death In a comprehensive analysis of pediatric HGG cases, PDGFRA mutations and/or amplifications were identified in 15% of cases ...

The researchers then demonstrated that blocking endocan's interaction with PDGFRA using the targeted ... endocan directly or disrupting its signaling pathways could open the door to new ...

We were excited to see that avapritinib essentially shut off PDGFRA signaling in mouse brain tumors ... like this and shutting down key oncogenic pathways. These results support a lot of ongoing ...

The researchers then demonstrated that blocking endocan’s interaction with PDGFRA using the targeted therapy drug ... These findings suggest that targeting endocan directly or disrupting its signaling ...

"We were excited to see that avapritinib essentially shut off PDGFRA signaling in mouse brain tumors ... like this and shutting down key oncogenic pathways. These results support a lot of ...

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a .

"We were excited to see that avapritinib essentially shut off PDGFRA signaling in mouse brain tumors ... like this and shutting down key oncogenic pathways. These results support a lot of ...