Can We Reverse Aging? Scientists Uncover a Key “Zombie Cell” Pathway
New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...
Scientists aim to repair or replace p53 to combat cancer
Over the years, scientists have devised various strategies to target the p53 pathway, or the network of molecules p53 ...
Nature12y
The p53 and RB tumour-suppressor pathways
p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...
Hosted on MSN1mon
Study reveals activity of navtemadlin in glioblastoma, points to possible treatment improvements
The researchers found that navtemadlin reached effective concentrations in the tumor and activated the p53 pathway, but the tumors eventually relapsed. The team then used tissue samples from three ...
bangaloremirror.indiatimes1mon
p53: A guardian and weak link
Targeting p53 pathways Given its crucial role in preventing cancer, p53 has become a major target for drug development. Over the years, scientists have devised various strategies to target the p53 ...
EurekAlert!10d
Cellular circuit controls how DNA damage is repaired, affecting risk of disease as we age
Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...
Medscape1mon
Lung Cancer Pathogenesis Associated With Wood Smoke Exposure
The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...