For example, by binding sterol regulatory ... and so could be used for cancer therapy. Mutant p53 clearly functions differently from wild-type p53, but there are some activities —such as the ...

For example, the investigators have found ... but among postmenopausal women with breast cancer, the presence of a p53 mutation was most commonly associated with higher body mass index (BMI ...

For example, MDM2 binds to TP53 mRNA ... repressors or downstream effectors of p53 might individually modulate cancer risk or interact with polymorphisms or mutations in TP53.

The explanation for p53 accumulation in tumour cells is a perfect example (see below ... the most frequent genetic alterations in human cancer (excluding gross genetic rearrangements) and ...

In other words, the activation of p53 in cancer cells can lead to a number ... especially to treat some types of tumors, for example, solid tumors in the colon, breast and lungs.

When you block both the major p53 repressor ... revealed additional pharmacological strategies to induce cancer cell death. For example, Andrysik and Espinosa repurposed the drug Nelfinavir ...

It is well known that mutations in P53 can lead to cancer, but it is now also becoming ... and hematopoietic stem cells are examples of possible predecessors of CAFs. This makes CAFs heterogenous.

RELATED: Capitalizing on a mutant p53 gene to fight pancreatic cancer The intense research ... A Stanford team, for example, found a mutated form of the gene that strengthens its ability to ...

A prominent example is the tumor suppressor p53, whose low expression levels and poor conformational stability hamper the development of cancer therapeutics,” the researchers wrote.

Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with polymorphisms or mutations in TP53. Because the effects of ...

"In the absence of growth factors, for example when there is not enough ... some of the most common mutations found in cancer cells happen in the p53 protein, a central player in the second ...