When p53 malfunctions, the result is often cancer. Learning about how p53 works has not only deepened how scientists understand cancer, but also provided promising avenues for new treatments.

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

Researchers at the Garvan Institute of Medical Research have uncovered how pancreatic cancer hijacks a crucial metabolism ...

Researchers found that the loss of p53 function led to the secretion of IL-34 directly. But the blockade of IL-34 restrained the growth of liver cancer with p53 inactivation, and thus prolonged ...

Scientists dive into the genomes of whales, elephants, and other animal giants looking for new weapons in the fight against ...

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...