Figure 3: The p53 pathway, polymorphisms, apoptosis and cancer therapy. In the NCI60 screen, the growth response to different chemotherapeutics and compounds was measured 48 hours after treatment ...

The p53 pathway is composed of a network of genes ... a program that induces cell senescence or cellular apoptosis (Jin and Levine, 2001). In this way, a variety of intrinsic or extrinsic stresses ...

Cells lacking p53 can still undergo apoptosis when their DNA is damaged, but the responsible pathways aren’t known, the authors continued. So while cancer treatments such as radiotherapy or ...

The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically engineered mice using knock-in and knockout ...

The most common translocation occurs when a gene (the apoptosis inhibitor ... If the cells did not die, p53 was not being inhibited by the NK-kB pathway. Sure enough, the cells died, leading ...

One pathway through which ROS and p53 are linked ... By regulating antioxidant and metabolism genes rather than cell cycle and apoptosis genes, p53 can aim to reduce ROS by encouraging antioxidant ...

In sum, p53/p16 inactivation is a difference between cancer and normal cells that hurts rather than helps when treatment goals are to activate apoptosis. Alternative pathways for antagonizing MYC and ...

Full details of the study are described in a Nature paper titled “Rewiring cancer drivers to activated apoptosis ... pathways including popular ones like TNF signaling and the p53 pathway.

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Invasion in bladder cancer forebodes a graver prognosis, and these tumors are generally characterized by alterations in the p53 and retinoblastoma (RB) pathways that normally ... suppression and ...

Discussion The presence of increased apoptosis and p53 in partial-thickness tears of the supraspinatus tendon is accompanied by features of both degeneration as well as ongoing repair. Apoptosis may ...