Nuclear localization and high levels of the Y-box binding protein YB1 appear to be important indicators of drug resistance and tumor prognosis. YB1 also interacts with the p53 tumor suppressor ...

Hypoxia inducible factors (HIF1, 2 and 3), consisting of α and β subunits, play an essential role in various responses to hypoxia. Nuclear entry of α subunits is a necessary step for the ...

The larger the molecule, the more nuclear localization signals are needed. A new study in the field of biophysics has revealed how large molecules are able to enter the nucleus of a cell.

In addition, the RFP-Cyto reporter lacks a nuclear localization signal, resulting in its mislocalization following the rupture of the nuclear membrane. Thus, the reporter is localized in the cytosol ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

we show that the nuclear localization of the mitochondrial enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) ensures mitosis progression,” they wrote. “Nuclear MTHFD2 interacts with ...

Its nuclear localization depends on the presence of 22G siRNAs synthesized by RNA-dependent RNA polymerases (RdRPs). Strikingly, in certain mutants of small RNA pathway factors (e.g., eri-1 ...

Further, SARS-CoV-2 S was analyzed using in silico analysis to investigate whether S resembled or constituted protein motifs such as a nuclear localization signal (NLS) and to study the ...