The ubiquitinylation pathway is executed by a series of ... The relative levels of NEDD8–cullin and NRF2 were estimated by quantitative immunoblot analysis (Li-cor Odyssey system) using Alexa680 ...

Alterations in the MET pathway were associated with type 1, and activation of the NRF2-ARE pathway was associated with type 2; CDKN2A loss and CIMP in type 2 conveyed a poor prognosis. Furthermore ...

NEDD8, was found to covalently modify cullin-family proteins; three proteins composed of this pathway were identified. Using a fission yeast system, NEDD8 was shown to regulate the cell cycle via the ...

Targeting the NRF2 pathway to reduce inflammatory damage offers the potential for a new approach to treat a variety of inflammatory diseases, such as COPD. Activation of NRF2 may help in reducing the ...