Notch receptors are 300- to 350-kDa type I transmembrane ... Figure 1: Notch domain organization and overall views of the structure. The NRR adopts a compact conformation with overall dimensions ...

As for the structural organization, all Notch proteins share a similar basic structure ... existence of redundancy between different Notch receptors and in particular, between Notch3 and Notch1 ...

Notch is a cell receptor that is of great importance to ... The researchers placed the protein on a DNA structure created by so-called DNA origami, a technique that makes it possible to build ...

Delta‐like canonical Notch ligand 3 (DLL3) belongs to the Notch receptor ligand family and ... growth factor-like domains make up the entire structure. DLL3 is commonly expressed in the Golgi ...

Now, two Yale-led studies published Nov. 24 in Nature reveal the structure of this molecule, opening new paths for cancer treatment development. The ALK molecule is a receptor — a protein that sits in ...

"Successful design of safer therapeutics has slowed because there is currently a limited understanding of the structure of the serotonin receptor itself, and what happens after serotonin binds ...

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time.

In a series of laboratory experiments, the investigators observed that Jagged1 on a tumor cell binds to molecules called Notch receptors on adjacent blood vessel–lining, or endothelial ...