We strongly support the idea of discarding the use of NL/MGCL syndrome, Noonan-cherubism or other specific ... Three of them have SOS1 mutations (two patients with facial giant cell lesions ...

Noonan syndrome is caused by a genetic defect. Scientists have identified four genes involved in the syndrome: PTPN11, SOS1, RAF1, and KRAS. There are two ways you can get this syndrome ...

Sevenless Therapeutics Ltd. has disclosed son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer, pain, dementia, Noonan syndrome, Parkinson's disease and ...

Scientists have discovered that mutations in a gene known as SOS1 account for many cases of Noonan syndrome (NS), a common childhood genetic disorder which occurs in one in 1,000-2,500 live births.

Revolution Medicines Inc. has divulged son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer, neurofibromatosis type 1, cardiofaciocutaneous, Noonan, Costello ...

The disease usually affects an individual by birth and the genes associated with Noonan syndrome include PTPN11, RAF1, SOS1 and KRAS. Patients affected with Noonan syndrome usually have extra skin on ...

In around half of all Noonan syndrome cases, PTPN11 genetic mutations cause the condition. SOS1 mutations occur in 10% to 15% of cases, and around 5% are due to RAF1 and RIT1 mutations.

Noonan syndrome is a genetic condition that affects around 1 in every 1,000–2,500 people. The signs and symptoms can vary greatly from person to person, so this condition may be underdiagnosed ...

Despite the lack of stringent diagnostic criteria, the principal features of Noonan syndrome are well established. These include short stature, congenital heart defects, unusual chest shape with ...

Noonan syndrome represents one of the most common dysmorphic disorders with an incidence between 1 in 1000 to 1 in 2500 live births. The most characteristic features of this syndrome are ...