At nodes, voltage-gated sodium channels are highly accumulated and ... The local differentiation of myelinated axons at nodes of Ranvier. Nature Reviews Neuroscience 4, 968–980 (2003).

The three best examples of ion channel/receptor clustering in the nervous system are found at the synapse, the node of Ranvier, and the axon initial segment (AIS). In the case of the synapse, the ...

Distribution of Ranvier nodes along myelinated axons is a critical determinant of conduction velocity, significantly influencing spike arrival timing and hence neural circuit function. The patterns of ...