Figure 2: aNSCs harbouring the Bcan-Ntrk1 deletion form high ... as enhancers or insulators, or affect gene expression by altering high-order chromatin structure 35. All mouse experiments were ...

Prevalence of new genetic driver in lung cancer shown in study Date: May 31, 2014 Source: University of Colorado Cancer Center Summary: A line has been drawn from mutation of the gene NTRK1, to ...

results of a University of Colorado Cancer Center study presented at ASCO 2013 show that mutations in the gene NTRK1 cause a subset of lung cancers. "We're reconceptualizing lung cancer as many ...

Scientists report on a gene fusion that spurs the cells to divide ... that blocks a protein encoded by one of those genes -- NTRK1 - caused the cells to die. The finding suggests that the fusion ...

A University of Colorado Cancer Center study presented at the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO) draws a line from mutation of the gene NTRK1, to its role as ...

“We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein),” wrote ...

Background: Tropomysin receptor kinase A (TrkA) is a protein encoded by the NTRK1 gene. NTRK fusions involving the kinase domain are oncogenic for multiple tumor types and larotrectinib was recently ...

One patient with an undifferentiated sarcoma with an LMNA-NTRK1 gene fusion has a confirmed partial response ongoing at eight months. One patient with a c-kit-negative gastrointestinal stromal ...

The FoundationOne CDx genomic test is now available to seek out patients who express the NTRK1/2/3 gene fusions, a rare mutation but one that hits across many solid tumors. This is good for ...

Sure enough, next-gen sequencing identified NTRK1 gene fusions as the potential driver in two of these samples. Doebele and colleagues took the lead back to the CU labs, where Marileila Varella ...