However, these samples are both resistant to crystallization (for X-ray diffraction) and do not reorient rapidly enough for solution-state NMR spectroscopy. The relatively few membrane protein ...

But NMR analysis of protein folding has typically involved ... and repeatedly impose and release very high pressure on NMR samples without destroying the equipment. The apparatus from the NIH ...

Fábio AlmeidaNational NMR CenterFederal University of Rio ... then happens to the structure and dynamics of the protein. In summary, sample preparation involves cloning the gene, expressing ...

The protein of focus, CAP-Gly ... required the development of new protocols for preparing the samples, new NMR experiments to gather various information on structure and dynamics, and new ...

Instead, IDPs sample multiple inter-converting conformations ... What do you think the future holds for protein research using NMR? I think these are very exciting times for NMR and NMR-based ...

The MAS-NMR technique, Gershenfeld says, “is the tool of choice for [analyzing] complex biological proteins in biologically meaningful environments.” For example, a sample could be analyzed in a ...

is therefore recommended to optimize NMR samples. These buffers usually contain salts (i.e. NaCl or KCl) which often increase protein solubility but may reduce signal to noise in cold NMR probes and ...

"We often need samples as large as 10 microliters, but with this approach we can use as little as one microliter or less," he said. "With protein structure work, preparing samples is a major ...

Chemists have found a way to shorten the time needed to obtain molecular structure imaging information from solid-state NMR ... "With protein structure work, preparing samples is a major ...