Natural killer T (NKT) cells are a developmentally and functionally distinct lineage of T cells restricted by CD1d–lipid antigen complexes. These cells branch from conventional MHC-restricted T ...

In this article we review the unique development and activation pathways of NKT cells and focus on how these attributes augment or exacerbate autoimmune disorders and malignancy. We also examine ...

Moreover, NKT cell activation indirectly promotes an anti-tumor response ... with Baylor with the goal of advancing therapeutic discoveries, accelerating drug development and improving patient ...

The KUR-501 development program is also designed to provide autologous proof-of-concept for CAR-NKT cells in solid tumors using a validated target and has extensive potential applications in the ...

The responses to DC-αGalCer — as assessed by the number of IFN-γ–secreting NKT cells— were stronger and more prolonged. In addition, DC-αGalCer was also associated with increased protection against ...

HOUSTON--(BUSINESS WIRE)--Kuur Therapeutics, a leader in the development of off-the-shelf CAR-NKT cell immunotherapies for the treatment of hematological and solid malignancies, today announced ...

Now, a newly published study by UNC Lineberger Comprehensive Cancer Center researchers demonstrates that a different immunotherapy approach utilizing natural killer T (NKT) cells produced ...

NKT cells were modified to express a GD2-specific chimeric antigen receptor (GD2 CAR), which enables the immune cells to target a molecule found on the surface of neuroblastoma cells, and ...

Moreover, NKT cell activation indirectly promotes an anti ... the goal of advancing therapeutic discoveries, accelerating drug development and improving patient outcomes." The NKT platform ...

Invariant NKT (iNKT) cells have a dual role in mouse models of diabetes. They appear to inhibit the development of diabetes, but can also promote pathogenic CD8 + diabetogenic T cells once they ...

Moreover, NKT cell activation indirectly promotes an anti ... the goal of advancing therapeutic discoveries, accelerating drug development and improving patient outcomes." The NKT platform ...