The authors of this article show that EGCG inhibited NEDD8, thus stabilizing HUWE1, a crucial E3 ubiquitin ligase involved in protein degradation. HUWE1 binds and degrades TFR1, a protein ...
Discovery of a NEDD8 modification system regulating the cell cycle: During in vitro translation analysis of full-length cDNA clones, a ubiquitin-like protein, NEDD8, was found to covalently modify ...
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