Nature3y
Vincerx—next-generation antibody–drug conjugates with enhanced therapeutic windows
In the second half of the 20th century, ADCs rapidly progressed from rudimentary constructs of polyclonal antibodies noncovalently linked to a cytotoxin, to mouse monoclonal antibodies (mAbs), and ...
The Scientist1y
Understanding Hybridoma Technology for Monoclonal Antibody Production
In contrast to polyclonal antibodies, monoclonals are highly specific ... 2 Since 1986, over 117 monoclonal antibodies have been FDA-approved, beginning with the mouse monoclonal antibody ...
News Medical3y
CAR-specific monoclonal FMC63 antibodies for CD19 CAR expression evaluation
In CAR-T therapy, CD19 is now the most extensively used target. It has been confirmed to be effective and safe for the treatment of CLL, B-ALL and B cell lymphoma. FMC63, an IgG2a mouse monoclonal ...
Nature1y
A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells
We used mouse monoclonal antibodies Hup1N and Hup2B ... GH1 was detected using a rabbit polyclonal antibody obtained from the National Hormone and Pituitary Program. We detected Tnp2 using ...
Medical Xpress22d
A chain reaction: HIV vaccines can lead to antibodies against antibodies
A technique invented by the lab, known as Electron Microscopy-Based Polyclonal Epitope Mapping (EMPEM), lets the researchers see exactly where on the HIV virus antibodies bind. When they carried ...