Although some of the biochemical pathways that involve modified bases have been identified, research into the world of RNA modification — the epitranscriptome — is still in an early phase.

For all modifications, the placement of these modified RNA bases was also crucial. When placed incorrectly, the modifications resulted in guide RNAs that did not function. “We hope the improved ...

Sequences representing RNA 'fragments' (55 or 75 bases) from KRT18 were centered ... were washed in 1 ml of diluted modified RIPA buffer (50 mM Tris PH 7.5, 1% Nonidet P-40 (NP-40), 0.1% sodium ...

For all modifications, the placement of these modified RNA bases was also crucial. When placed incorrectly, the modifications resulted in guide RNAs that did not function. "We hope the improved ...

A new study shows that modified RNA bases have a great impact on the dynamics of gene expression from DNA to functional RNA. RNA modifications can encrypt the RNA code and are responsible for a ...

For all modifications, the placement of these modified RNA bases was crucial. When placed incorrectly, the modifications resulted in guide RNAs that did not function. Neville Sanjana, PhD “These ...

RNA base to guanosine (G). The method is based on yet another RNA-targeting enzyme called Cas13b. The team modified Cas13b so that it binds RNA but doesn’t cut it, and then they attached part of ...

For all modifications, the placement of these modified RNA bases was also crucial. When placed incorrectly, the modifications resulted in guide RNAs that did not function. "We hope the improved ...

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...

CAMBRIDGE, Mass., March 07, 2022 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage genetic medicines company committed to delivering life-changing treatments for people ...

The team also found that adding three bases with a different type of ... We anticipate that chemically modified crRNAs for RNA-targeting CRISPRs will be useful for both in vitro RNA diagnostics ...