The study, published in the journal Neuron, emphasizes the dual role of microglia in the brain ... observing previously unseen cells under the microscope, as reported by La Nación.

“It’s not clear whether microglia are…facilitating the progression of these diseases or trying to block the progression…to save the neuron,” said Zurzolo. Zurzolo’s team first determined if functional ...

The study, published in the journal Neuron, highlights microglia, the brain's primary immune cells, as central players in both the protective and harmful responses associated with the disease.

iAssembloids combine hiPSC-derived neurons, microglia, and astrocytes in 3D spheres. CRISPRi screening revealed genes that affect neuron survival in iAssembloids but not in 2D monoculture. One gene, ...