Mast cells (MCs) are critical components of the ... and in vitro assays suggested a slowing of MC terminal differentiation in the context of LIN28B upregulation. Finally, interrogation of human ...

Mast cells develop from hematopoietic progenitors in response to stem-cell factor (KIT ligand), which is the ligand of the CD117 transmembrane tyrosine kinase receptor, encoded by KIT. CD117 ...

Remarkably, the mast cells generated using our method expressed ... They generated induced MMCs by in vitro differentiation of bone marrow cells derived from mice. In vitro antigen presentation ...

When our body requires defending from “non-self” entities, it deploys immune cells. This diverse group performs a wide variety of specialized functions to prevent us becoming ill. Mast cells have ...

We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle. Immunohistochemical analysis of bronchial ...

More information: Kenji Oishi et al, MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy, Allergy (2025). DOI: 10.1111/all.16477 ...

Certain immune cells backstab their cellular coworkers during allergic reactions. Mast cells, the security patrols of the immune system, can trigger allergic inflammation when they run into ...