They discovered that the MCM complex plays an important role in restricting DNA loop formation and thus in the three-dimensional structure of the genome and in gene regulation. A DNA molecule is about ...

More information: Yuanliang Zhai et al, Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer, Nature Structural & Molecular Biology (2017). DOI: 10.1038 ...