20–22 We have maintained dogs on large doses of hydralazine for more than a year and have been unable to produce lupus-like disease. Since the syndrome develops in 8 to 13 per cent of ...

However, symptoms often overlap with those of systemic lupus erythematosus (SLE). These include: muscle and joint pain sometimes with swelling flu-like symptoms of fatigue and fever serositis ...

and investigated the outcomes of proteasome inhibition in mice with lupus-like disease. The researchers found that, for the depletion of total and long-lived plasma cells in mouse bone marrow ...