U sing computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) ...

This work follows his 2017 discovery that knocking out 12/15 lipoxygenase, or 12/15LOX, a lipid-modifying enzyme that competes with two other lipid-modifying enzymes, leads to increased survival ...

New research in the FASEB Journal suggests that the 5-lipoxygenase enzyme mediates microgravity-induced lymphocyte programmed cell death and its inhibition could help astronauts and the elderly ...

Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n–6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation ...

Treatment with an inhibitor of 12/15-lipoxygenase, an enzyme elevated in patients with Alzheimer's disease (AD), reverses cognitive decline and neuropathology in an AD mouse model, reports a new ...

According to Domenico Praticò, an associate professor of pharmacology in Temple's School of Medicine and the study's lead researcher, the 5-Lipoxygenase enzyme is found in abundance mainly in the ...

5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment. The FASEB Journal , 2012; 26 (5): 1791 DOI: 10.1096/fj.11-199406 Cite ...

New research in the FASEB Journal suggests that the 5-lipoxygenase enzyme mediates microgravity-induced lymphocyte programmed cell death and its inhibition could help astronauts and the elderly ...

New research published online in the FASEB Journal suggests that a specific enzyme, called 5-lipoxygenase, plays a key role in cell death induced by microgravity environments, and that inhibiting ...