But now Bowen Tan, Kristina Hedbacker, and other researchers in Friedman's Laboratory of Molecular Genetics have discovered a ...

Since the discovery in 1994 of the obesity gene and its product, the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity - ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

Friedman’s laboratory at the Rockefeller University cloned the leptin gene in 1994. “Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

Leptin, the satiety hormone produced by fat, affects neuronal signaling in the mouse brain; interference with this pathway can influence the rewarding effects of running in the animals. “Based on ...

Leptin, a hormone primarily produced in the fat cells of the ... In this project, student researchers will work with laboratory mice, gaining hands-on experience in behavior studies. The student will ...

These mice demonstrated increased food intake and ... in the brain reduced food intake and increased sensitivity to leptin, the “fullness” hormone, confirming that neuroestrogens can influence ...

Clinical trials with r-Met-hu-leptin were also performed for the treatment of hypothalamic amenorrhea, where a 3-month administration resulted in the appearance of spontaneous menstrual cycles ...

As the researchers describe in a paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced obese mice, leading to significant loss of fat with only minimal effects ...