In the original lentivirus vectors described by Naldini et al (Naldini et al., 1996a) (Naldini et al., 1996b) , the vector pCMVΔR8.2 supplies all but the HIV envelope in trans, the vector pMD.G is ...

Partial hepatectomy did not affect serum ALT levels in animals that received lentivirus (Fig. 3). The observed liver injury may be a direct toxic effect of the viral particles or contaminants in ...

Among these, lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing ...